S
- Saafir (Qwest/Reprise)
- Mort Sahl
- David Sanborn
- Ed Sanders
- Savage Grace
- SchascleSchascle
- Schleprock
- Randy Scruggs
- Brady Seals
- John Sebastian
- Taja Sevelle (Paisley Park/Reprise)
- Roxanne Shanté (Cold Chillin'/Reprise)
- Victoria Shaw
- Vonda Shepard
- Shootyz Groove (Kinetic/Reprise)
- Dinah Shore
- Jane Siberry
- Frank Sinatra
- Nancy Sinatra
- Single File
- Slapbak
- The Smashing Pumpkins
- The Smiths (Sire/Reprise)
- Keely Smith
- Snake River Conspiracy
- Sonny & Cher
- Spectrum
- Jo Stafford
- Stress
- Streetwalkers
- Submarine (Kinetic/Reprise)
- Sweetwater
Read more about this topic: List Of Former Reprise Records Artists