S
- Saukrates
- Shawnna (Disturbing Tha Peace/Def Jam)
- Serius Jones (Disturbing Tha Peace/Def Jam)
- State Property (Roc-A-Fella/State Property/Def Jam)
- Shorty 101
- Short Dawg (Russell Simmons Music Group/Def Jam)
- Shyne (Gangland/Def Jam)
- Sisqó (Dragon/Def Soul/Def Jam)
- Sizzla (Dame Dash Music Group/Def Jam)
- Slayer
- Slick Rick
- South Central Cartel
- Static Major (Blackground/Def Jam)
- Steph Jones (Disturbing Tha Peace/Def Jam)
- Jimmy Spicer
- Warren Stacey
- Chuck Stanley (OBR/Def Jam)
- The Suburban Boyz
Read more about this topic: List Of Former Def Jam Recordings Artists