S
- Lætitia Sadier (Stereolab)
- Santi White (Stage name Santigold)
- Saffron (Republica)
- Svetlana Surganova
- Julz Sale (Delta 5)
- Emily Saliers (Indigo Girls)
- Greta Salpeter (The Hush Sound)
- Hope Sandoval (Mazzy Star, Hope Sandoval & the Warm Inventions)
- Simi Sernaker (Suffrajett)
- Sarah Shannon (Velocity Girl)
- Kim Shattuck (The Muffs, The Pandoras)
- Alison Shaw (The Cranes)
- Davetta Sherwood
- Shery
- Madigan Shive (Tattle Tale, Bonfire Madigan)
- Sharon Shy (The Ropes)
- Juliet Simms (Automatic Loveletter)
- Carly Simon
- Siouxsie Sioux (Siouxsie and the Banshees, The Creatures)
- Katie Sketch (The Organ)
- Skin (Skunk Anansie)
- Grace Slick (Jefferson Airplane, Jefferson Starship, Starship)
- Tara Slone (Joydrop)
- Jen Smith (Dub Narcotic Sound System)
- Patti Smith
- Shawnee Smith
- Carly Smithson (We Are the Fallen)
- Patty Smyth (Scandal)
- Azalia Snail
- Marla Sokoloff (Smitten)
- Pepper Somerset (My Life With The Thrill Kill Kult)
- Louisa Rachel Solomon (The Shondes)
- Donita Sparks (L7)
- Regina Spektor
- Pamela Spence
- Sharleen Spiteri (Texas)
- Adalita Srsen (Magic Dirt)
- Becky Stark (Lavender Diamond)
- Ryan Starr
- Alison Statton (Young Marble Giants, Weekend)
- Gwen Stefani (No Doubt)
- Marnie Stern
- Linda Strawberry
- Laura Stoica
- Helen Storer (Thee Heavenly Music Association)
- Poly Styrene (X-Ray Spex)
- Alison Sudol (A Fine Frenzy)
- Donna Summer
- Lacey Sturm (Flyleaf (band))
- Verity Susman (Electrelane)
- Rachel Sweet
Read more about this topic: List Of Female Rock Singers