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- Jeanne Sagan (from The Acacia Strain, All That Remains)
- Shiori Sekine (from Base Ball Bear)
- Kim Shattuck (formerly of The Pandoras, now singer/guitarist for The Muffs)
- Shingai Shoniwa (from Noisettes)
- Melanie Sisneros (from Crescent Shield, Whole Lotta Rosies, Hangar 18, Mz Led formerly of The Iron Maidens, Sinergy, New Eden)
- Grace Slick (formerly of Jefferson Starship, Starship, Jefferson Airplane, The Great Society) was primarily a singer, but sometimes played bass or other instruments for The Great Society
- Donita Sparks (from Donita Sparks and The Stellar Moments and L7)
- Debbie Smith (from Echobelly)
- Esperanza Spalding
- Malka Spigel (from Githead and Minimal Compact)
- Micki Steele (from The Bangles, formerly of The Runaways)
- Laurie Stirratt (from Blue Mountain and Healthy White Baby)
Read more about this topic: List Of Female Bass Guitarists