U
- UltrAir (1993)
- United States International Airlines
- Universal Air Lines Corporation (1928–1934, to American Airlines)
- Universal Airlines (US Cargo Operator 1966 - 1972, to Trans International Airlines)
- US Air (1979-1996; renamed US Airways)
- USA3000 Airlines (Ceased operations in 2012)
Read more about this topic: List Of Defunct Airlines Of The United States