S
- Soony Saad, Sporting Kansas City
- Alvaro Saborío, Real Salt Lake
- Omar Salgado, Vancouver Whitecaps FC
- Hamdi Salihi, D.C. United
- Shea Salinas, San Jose Earthquakes
- Lloyd Sam, New York Red Bulls
- Richard Sanchez, FC Dallas
- Maicon Santos, D.C. United
- Camilo Sanvezzo, Vancouver Whitecaps FC
- C. J. Sapong, Sporting Kansas City
- Marcelo Saragosa, D.C. United
- Kofi Sarkodie, Houston Dynamo
- Marcelo Sarvas, Los Angeles Galaxy
- Josh Saunders, Los Angeles Galaxy
- Aaron Schoenfeld, Columbus Crew
- Chris Schuler, Real Salt Lake
- Zach Scott, Seattle Sounders FC
- Scott Sealy, FC Dallas
- Mike Seamon, Seattle Sounders FC
- Gonzalo Segares, Chicago Fire
- Chris Seitz, FC Dallas
- Saër Sène, New England Revolution
- Conor Shanosky, D.C. United
- Brek Shea, FC Dallas
- Bobby Shuttleworth, New England Revolution
- Luis Silva, Toronto FC
- Clyde Simms, New England Revolution
- Seth Sinovic, Sporting Kansas City
- Jamie Smith, Colorado Rapids
- Ryan Smith, Chivas USA
- Steven Smith, Portland Timbers
- A. J. Soares, New England Revolution
- Babayele Sodade, Seattle Sounders FC
- Jan Gunnar Solli, New York Red Bulls
- Frank Songo'o, Portland Timbers
- Josue Soto, Houston Dynamo
- Bakary Soumaré, Philadelphia Union
- Ben Speas, Columbus Crew
- Jonny Steele, Real Salt Lake
- Michael Stephens, Los Angeles Galaxy
- Khari Stephenson, San Jose Earthquakes
- Daniel Steres, Seattle Sounders FC
- Matt Stinson, Toronto FC
- Nathan Sturgis, Houston Dynamo
Read more about this topic: List Of Current Major League Soccer Players