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- Donald Saddler (May 25, 2007)
- Bob Saget (signed "Thank you, Sardi's. I haven't ever looked towards this wall with such respect before. Bob Saget")
- Lea Salonga
- Diana Sands
- Marie Saxon by Alex Gard (Housed in the Billy Rose Theatre Collection of the New York Public Library)
- Tito Schipa by Alex Gard (Housed in the Billy Rose Theatre Collection of the New York Public Library)
- Gerald Schoenfeld (theatrical producer) by Richard Baratz
- Louis Schonceit by Alex Gard (Housed in the Billy Rose Theatre Collection of the New York Public Library)
- Annabella Sciorra
- Thomas Schumacher (Mary Poppins producer. Signed "Holly Cow, Who the hell is that?!? ~". He meant to write "Holy Cow~".)
- Paul Scofield
- George C. Scott by Richard Baratz
- Sherie Rene Scott (Dirty Rotten Scoundrels, 5 May 2005)
- Oscar Serlin by Alex Gard (Housed in the Billy Rose Theatre Collection of the New York Public Library)
- Jane Seymour (Amadeus April 23, 1981)
- Michael Shannon (Grace, October 9, 2012)
- William Shatner
- Julia Shawell by Alex Gard (Housed in the Billy Rose Theatre Collection of the New York Public Library)
- Michael Sheen ("Frost/Nixon", August 10, 2007)
- Tony Sheldon
- Carole Shelley
- Brooke Shields
- Samuel Shipman by Alex Gard (Housed in the Billy Rose Theatre Collection of the New York Public Library)
- Martin Short
- Lee Shubert
- Sylvia Sidney
- Christopher Sieber
- Beverly Sills
- Douglas Sills (The Scarlet Pimpernel, 4 June 1998)
- Phil Silvers
- Neil Simon (Don Bevan)
- Hugh Sinclair by Alex Gard (Housed in the Billy Rose Theatre Collection of the New York Public Library)
- Menasha Skulnik
- Christian Slater
- Liz Smith by Richard Baratz
- Maggie Smith
- Rex Smith (The Scarlet Pimpernel, 20 January 1999)
- Stanley Smith by Alex Gard (Housed in the Billy Rose Theatre Collection of the New York Public Library)
- Louis Sobol
- Suzanne Somers
- Stephen Sondheim
- Paul Sorvino by Richard Baratz
- James Spader (RACE, 2010) '
- John Stamos
- Dave Stamper by Alex Gard (Housed in the Billy Rose Theatre Collection of the New York Public Library)
- Barbara Stanwyck
- Jean Stapleton
- John Steinbeck
- Patrick Stewart
- Dorothy Stickney
- Jerry Stiller by Richard Baratz
- Lee Strasberg
- Elaine Stritch
- Ed Strong (Dodger Productions, 21 October 1997)
- Ed Sullivan by Don Bevan (Housed in the Billy Rose Theatre Collection of the New York Public Library)
- Gloria Swanson
- Will Swenson
- Kay Swift 1987, to honor her 90th birthday
Read more about this topic: List Of Caricatures At Sardi's Restaurant