S
- Shakura S'Aida - blues/jazz singer-songwriter
- Martine St-Clair – pop singer
- Buffy Sainte-Marie – singer, songwriter, artist, activist
- Samian - rapper
- Gordie Sampson – blues/rock singer
- John K. Samson - indie rock singer and songwriter (The Weakerthans)
- Chase Sanborn – jazz trumpet player
- Curtis Santiago – dance rock singer-songwriter
- Ivana Santilli – R&B singer
- Saukrates - rapper
- Andrew Scott – power pop singer/songwriter/drummer, Sloan
- Dazzer Scott - drummer/programmer, Die Mannequin
- Jack Scott – early rock and roll singer
- Jennifer Scott – jazz singer and pianist
- Jonathan Seet – singer-songwriter
- Lorraine Segato – singer-songwriter
- Jay Semko – singer-songwriter and bass player
- Ron Sexsmith – singer-songwriter
- Shad - rapper
- Paul Shaffer – musical director
- Remy Shand – R&B/soul singer
- Bernie Shaw - rock singer from Uriah Heep
- Buzz Shearman - rock singer-songwriter (Moxy), (Leigh Ashford)
- Shiloh - pop singer and songwriter
- Stefie Shock – Quebec pop, funk
- Howard Shore – Grammy Award-winning composer, best known for composing the scores to The Lord of the Rings film trilogy and films of David Cronenberg
- Shotgun Jimmie - singer-songwriter
- Jane Siberry – singer-songwriter
- Lucas Silveira - rock singer/guitarist
- Liberty Silver - R&B singer
- Nathalie Simard – pop singer
- René Simard – pop singer
- Denis Simpson - singer
- Shane Simpson – guitar virtuoso and singer-songwriter
- Sixtoo - hip hop DJ & MC
- Amy Sky – singer-songwriter
- Slakah the Beatchild - soul/R&B singer and record producer
- Sarah Slean – singer, songwriter, pianist
- Berris Smith - rapper
- Laura Smith - folk singer
- Maybe Smith – indie pop singer-songwriter
- Meaghan Smith - singer
- Samantha Savage Smith - singer-songwriter
- Dan Snaith - songwriter
- Floyd Sneed - rock drummer
- Bob Snider – folk singer-songwriter
- Jason Sniderman - keyboardist (Blue Peter)
- Snow – reggae/rap/pop musician
- Hank Snow – country & western singer
- Bryce Soderberg – bassist for Lifehouse
- Viviana Sofronitsky - pianist
- Theresa Sokyrka – best known as Canadian Idol semi finalist
- Solitair - rapper
- Aaron Solowoniuk - Billy Talent's drummer
- Harry Somers – composer
- Martina Sorbara – folk-pop singer
- Jay Sparrow - rock singer-songwriter
- Rae Spoon - folk/indie singer-songwriter
- Tony "Wild T" Springer - blues/rock guitarist
- Frederick Squire - rock singer/guitarist (Shotgun & Jaybird, Calm Down It's Monday)
- Leeroy Stagger – singer-songwriter
- Ethel Stark - violinist and conductor
- Kinnie Starr – singer-songwriter
- Lucille Starr – singer
- Cassie Steele – singer-songwriter and actress
- Katie Stelmanis - singer-songwriter
- Ian Stephens punk rock musician
- Tyler Stewart - drummer
- Jeff Stinco - rhythm-guitarist Simple Plan
- Georgina Stirling – singer
- Andy Stochansky – singer-songwriter and former drummer for Ani DiFranco
- Kim Stockwood – singer
- Jayme Stone – banjoist and composer
- Miranda Stone - singer-songwriter
- Amanda Stott – singer
- Byron Stroud – bassist for Strapping Young Lad and Fear Factory
- Mark Sultan – singer-songwriter, Sultan Records founder
- Harold Sumberg – violinist
- Cree Summer - rock/alternative singer
- Michelle Sweeney - jazz singer
- Skye Sweetnam – singer-songwriter
- Tomi Swick – singer-songwriter
- Ember Swift – singer-songwriter
- Kurt Swinghammer – singer-songwriter
- Jack Syperek – bassist, (The Trews)
Read more about this topic: List Of Canadian Musicians