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- Robert Treat Paine – Signer of the Declaration of Independence
- Amanda Palmer – Songwriter and Performer
- Trey Parker – Co-creator of South Park
- Evelyn Parnell – Opera singer
- George Patton IV – US Army General and famed son of World War II General George S. Patton III
- The Perceptionists – Rap Group
- Esther Petrack – Contestant on America's Next Top Model, Cycle 15
- John Pinette – Actor and Comedian
- Sylvia Plath – Poet and author
- Edgar Allan Poe – Poet and writer
- Tom Poti – NHL player, Washington Capitals
- Powerman 5000 – Metal Band
- The Pixies – Band
- Seth Putnam - Musician
- Piebald – Indie rock band
- Ellen Pompeo – Actress
- PJ Ladd – Professional Skateboarder
Read more about this topic: List Of Bostonians