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- Aimee Mann – Singer
- Rob Mariano – Survivor Contestant
- Marky Mark and the Funky Bunch – Rap Group
- Jonah Matranga – Singer/Songwriter
- Cotton Mather – Puritan minister and author
- Greg Mauldin – NHL Player, Ottawa Senators
- John Mayer – Singer/Songwriter (Born in Connecticut lived in Boston)
- Jack McCarthy – Poet
- Tommy McCarthy, major league baseball player
- John P. McDounough – Chief of Chaplains of the U.S. Air Force
- Neal McDonough – Actor
- Sean McDonough – Sports announcer
- Will McDonough – Writer
- Joey McIntyre – Singer/Dancer/Actor (See New Kids on the Block)
- Ed McMahon – Television personality
- Masspike Miles - Singer/song writer/producer Perfect Gentlemen (Maybach Music Group)
- Peter McNeeley – Boxer
- Michael McShane – Actor
- Connie Martinson - Talk show host
- Nelson Merced, Latino activist and politician. He was the first Hispanic elected to the Massachusetts General Court
- David Merkow – Golfer
- The Mighty Mighty Bosstones – Band
- Wayne Millner – NFL Hall of Famer
- Joe Moakley – Congressman
- William Monahan – Screenwriter
- Van Morrison – Singer, musician, Rock and Roll Hall of Fame Inductee in 1993 (born in Belfast, Northern Ireland, has made his home in Boston for years)
- Robert Morse – Actor
- Samuel F. B. Morse – Inventor and painter, best known for invention of the electric telegraph and Morse code
- Morphine – Band
- Eddie Mottau – Guitarist
- Mission of Burma – Band
- Roger Miller – Musician
- Mr. Lif – Hip Hop artist, member of The Perceptionists
Read more about this topic: List Of Bostonians