E
- Ed O.G. – Hip Hop Artist
- Richard J. Egan – Founder and Retired Chairman of EMC Corporation
- Ralph Waldo Emerson – American essayist
- Ernie and the Automatics – Band
- Mike Eruzione – Captain of the United States' 1980 Winter Olympics hockey team (from Boston suburbs)
- Julius Erving – NBA Hall of Famer, New York Nets, Philadelphia 76ers
- 7L & Esoteric – Rap Group
- William Eustis, Early American statesman, Governor of Massachusetts
- Patrick Ewing – NBA Hall of Famer, New York Knicks
- Patrick Ewing, Jr. – NBA player, New York Knicks, New Orleans Hornets
- Extreme – Band
Read more about this topic: List Of Bostonians