D
- Da Bulldogs – Rap Group
- Dick Dale – Musician
- Matt Damon – Actor
- Evan Dando – Musician
- Al Davis – President/General Manager of the NFL Oakland Raiders
- Bette Davis – Actress
- Geena Davis – Actress
- Henry Dearborn, Physician, general, and politician
- Henry Alexander Scammell Dearborn, Lawyer, author, statesman, soldier, Mayor of Roxbury, and son of Henry Dearborn.
- Death Before Dishonor – Band
- Patrick DeCoste – Musician
- Manny Delcarmen – Texas Rangers Pitcher
- Becky DelosSantos – Playboy Playmate – Centerfold: April 1994
- Brad Delp – Singer
- Tony DeMarco - Welterweight champion of the world born January, 14th, 1932 in the North End section of Boston, MA.
- Joseph Dennie – Writer
- Joe Derrane (born 1930) – accordion player
- Michael Dertouzos (1936–2001) – computer scientist
- Albert DeSalvo – Serial killer known as 'The Boston Strangler'
- Sara Diamond - Scientologisy and attorney
- Dinosaur Jr. – Band
- Rick DiPietro - ice hockey goaltender currently playing for the New York Islanders of the NHL (from Boston suburbs)
- Ken Doane – Former WWE Wrestler
- Dresden Dolls – Punk-Cabaret Duo
- Dropkick Murphys – Band
- Shem Drowne – America's first weathervane maker
- W. E. B. Du Bois – Civil rights activist, Founder of the NAACP
- Joseph Dudley, Colonial Governor of MassachusettsEliza
- Michael Dukakis – Massachusetts governor, US Presidential candidate in 1988
- Olympia Dukakis – Actress
- William C. Durant – Founder of General Motors
- Adam Duritz – Singer/Songwriter for Counting Crows (Born in Baltimore MD, lived in Boston)
- Eliza Dushku – Actress
- P. T. Deutermann – Author
- Mary Dyer – Martyr
Read more about this topic: List Of Bostonians