C
- C60 – Band
- Will Calhoun – Drummer for Living Colour (Born in NY lived in Boston)
- Steve Carell – Comedian; stars in the hit show The Office
- The Cars – Band
- Peggy Cass – Actress, Comedian and Game Show Panelist
- John Cazale – Actor
- John Cena – WWE wrestler
- Ken Cheeseman – Actor
- Gary Cherone – Singer (Extreme and Van Halen)
- Michael Chiklis – Actor
- Lenny Clarke – Comedian and actor
- The Click Five – Band
- John A. Collins – Chief of Chaplains of the U.S. Air Force
- Misha Collins – Actor
- Jerry Colonna – Entertainer
- Greg Comella – Former NFL Fullback
- Dane Cook – Comedian and actor
- Calvin Coolidge – 30th President of the U.S.A.
- Jennifer Coolidge – Actress
- John Singleton Copley – Artist
- Chick Corea – Grammy Award winning jazz musician and composer
- Jeff Corwin – TV personality
- Zach Cregger – Actor, Comedian, star of the IFC sketch comedy series WKUK
- Norm Crosby – Comedian
- Marcia Cross – Actress
- James Michael Curley – Mayor of Boston, Massachusetts governor, and US Representative
- Jane Curtin – Actress and Comedienne
- Johnny Curtis – WWE wrestler
- Richard Cushing – Archbishop of Boston and Cardinal of the Roman Catholic Church
- Susan Webb Cushman (1822–1859), born in Boston, stage actress
- Louis C.K. – Comedian and actor
- Neil Cicierega - Internet Personality. Created Potter Puppet Pals.
Read more about this topic: List Of Bostonians