A
- Abiel Abbot (1770–1828), born in Andover, Massachusetts, clergyman and author
- Benjamin Abbot (1762–1849), born in Andover, Massachusetts, noted teacher at the Phillips Exeter Academy
- Ezra Abbot (1819–1884), noted biblical scholar, taught at Harvard Divinity School
- Joel Abbot (1776–1826), naval officer
- Amos Abbott (1786–1868), born in Westford, Massachusetts, member of the United States House of Representatives from Massachusetts
- Austin Abbott (1831–1896), born in Boston, noted lawyer, novelist, and academic
- Benjamin Vaughan Abbott (1830–1890), born in Boston, lawyer and legal writer
- Joseph Carter Abbott (1825–1882), publisher of the Boston Bee
- Josiah Gardner Abbott (1814–1891), member of United States House of Representatives
- Abigail Adams (1744–1818), born in Weymouth, Massachusetts, First Lady of the United States
- Abijah Adams (1754–1816), born in Boston, noted journalist, often embroiled in lawsuits against him
- Charles Francis Adams, Sr. (1807–1886), born in Boston, son of Abigail Adams and John Adams, Congressman, diplomat, and writer
- Edwin Adams (1834–1877), born in Medford, Massachusetts, notable 19th century stage actor
- Eliphalet Adams (1677–1753), born in Medford, Massachusetts, clergyman and missionary
- Hannah Adams (1755–1831), born in Medfield, Massachusetts, famous Christian writer
- Henry Adams (1838–1918), born in Boston, Massachusetts, journalist, historian, academic and novelist
- Jasper Adams (1793–1841), born in Medway, Massachusetts, clergyman and college president
- John Adams – Second President of the United States, signer of the Declaration of Independence
- John Quincy Adams – Sixth President of the United States
- Nehemiah Adams (1806–1878), clergyman and author
- Samuel Adams – American Revolution patriot, signer of the Declaration of Independence
- Samuel Adams Wisner – Musician
- Aerosmith – Band
- Ben Affleck – Actor
- Casey Affleck – Actor
- George Aiken (1830–1876), born in Boston, noted actor and playwright
- Amos T. Akerman (1821–1880), former United States Attorney General, born in Portsmouth, New Hampshire
- Akrobatik – Hip Hop Artist, member of The Perceptionists
- Al B. Sure – Singer
- Louisa May Alcott – Author
- Horatio Alger, Jr. – Author
- Fred Allen – Radio Comedian
- Frederick Lewis Allen – Writer
- Joseph Allen (1749–1827), born in Boston, United States Congressman
- The Almighty RSO – Rap Group
- John Amaechi – Former NBA basketball player
- American Hi-Fi – Band
- Amerie – R&B Artist
- Ed Ames – Actor
- Tony Amonte – Former NHL hockey player
- Anarchy Club – Band
- Leroy Anderson – Composer for the Boston Pops Orchestra
- Mary Antin – Author
- Apollo Sunshine – Band
- Thomas Gold Appleton (1812–1884), born in Boston, noted American writer
- Crispus Attucks – American Revolution patriot
- Red Auerbach – Boston Celtics Coach
- John Augustus (1785–1859), born in Boston, noted philanthropist and pioneer of probation
- James Trecothick Austin (1784–1870), born in Boston, member of Massachusetts General Court and Massachusetts Attorney General
- Jonathan Loring Austin (1748–1826), born in Boston, officer in the American Revolutionary War and Massachusetts state representative, senator, secretary, and treasurer
Read more about this topic: List Of Bostonians