2000s
- The Amazing Adventures of Kavalier & Clay - Michael Chabon (2000)
- Bodega Dreams - Ernesto Quinonez (2000)
- City of God - E.L. Doctorow (2000)
- Killing Time - Caleb Carr (2000)
- Murder in Central Park - Michael Jahn (2000)
- The Night Inspector - Frederick Busch (2000)
- The Princess Diaries (series) - Meg Cabot (2000)
- Redemption Song - Bertice Berry (2000)
- The 25th Hour - David Benioff (2000)
- The Toy Collector - James Gunn (2000)
- Minor Miracles - Will Eisner (2000)
- Murphy's Law - Rhys Bowen (2001)
- About the Author - John Colapinto (2001)
- Bad Connection - Michael Ledwidge (2001)
- Because She is Beautiful - Cameron Dougan (2001)
- Black Water Transit - Carsten Stroud (2001)
- Borrowed Tides - Paul Levinson (2001)
- Box Office Poison - Alex Robinson (2001)
- Clara Callan - Richard B. Wright (2001)
- Closing Time -Jim Fusili (2001)
- The Corrections - Jonathan Franzen (2001)
- Dog Bites Man! City Shocked! - James Duffy (2001)
- Fixer Chao - Han Ong (2001)
- The Foreigner - Meg Castaldo (2001)
- The Fourth Angel -Suzanne Chazin (2001)
- Going, Going, Gone - Jack Womack (2001)
- The Good People of New York - Thisbe Nissen (2001)
- The Grand Complication - Allen Kurzweil (2001)
- The Haunting of Hip Hop - Bertice Berry (2001)
- Hell's Kitchen - Chris Niles (2001)
- High Maintenance - Jennifer Belle (2001)
- Hot Wired in Brooklyn - Douglas Dinunzio (2001)
- The Hum Bug - Harold Schechter (2001)
- Jeremy Thrane - Kate Christensen (2001)
- Kissing in Manhattan - David Schickler (2001)
- Lit Life - Kurt Wenzel (2001)
- Look at Me - Jennifer Egan (2001)
- Lucky Us- Joan Silber (2001)
- The Manhattan Hunt Club - John Saul (2001)
- The Muse Asylum - David Czuchlewski (2001)
- Rivington Street - Meredith Tax (2001)
- Saturn's Return to New York - Sara Gran (2001)
- Shooting Dr. Jack - Norman Green (2001)
- The Sweet By and By - Jeanne MacKin (2001)
- Death of Riley - Rhys Bowen (2002)
- Absolute Rage - Robert K. Tanenbaum (2002)
- Confessions of an Ex-Girlfriend - Lynda Curnyn (2002)
- The Consciousness Plague - Paul Levinson (2002)
- Disturbing the Peace - Nancy Newman (2002)
- Dreamland - Kevin Baker (2002)
- Gramercy Park - Paula Cohen (2002)
- Little Girl Blue - David Cray (2002)
- The Nanny Diaries - Emma McLaughlin & Nicola Kraus (2002)
- The Navigator of New York - Wayne Johnston (2002)
- Only Child - Andrew Vachss (2002)
- Paradise Alley - Kevin Baker (2002)
- Pipsqueak - Brian Wiprud (2002)
- Save Karyn - Karyn Bosnak (2002)
- Shopaholic Takes Manhattan - Sophie Kinsella (2002)
- The Tea Rose - Jennifer Donally (2002)
- Three Junes - Julia Glass (2002)
- For the Love of Mike - Rhys Bowen (2003)
- The Anniversary - Amy Gutman (2003)
- Beautiful Bodies - Laura Cunningham (2003)
- Carrie Pilby - Caren Lissner (2003)
- The Cordelia Squad - Mary Anne Kelly (2003)
- Cosmopolis - Don DeLillo (2003)
- A Cruel Season for Dying - Harker Moore (2003)
- Dead For Life - Ethan Black (2003)
- The Devil Wears Prada - Lauren Weisberger (2003)
- Diary of a Mad Mom to Be -Laura Wolf (2003)
- Empty Stockings - Denis Hamill (2003)
- Engaging Men - Lynda Curnyn (2003)
- Forever - Pete Hamill (2003)
- For Matrimonial Purposes - Kavita Daswani (2003)
- The Furies - Fernanda Eberstadt (2003)
- Girl Cook - Hannah McCouch (2003)
- Hex - Maggie Estep (2003)
- Imitation in Death -J.D. Robb (2003)
- A Killing Gift - Leslie Glass (2003)
- Kunma - Frank Corsaro (2003)
- The Last Good Day - Peter Blauner (2003)
- Love Me - Garrison Keillor (2003)
- Lucia, Lucia - Adriana Trigiani (2003)
- Manhattan North - John Mackie (2003)]
- Moral Hazard - Kate Jennings (2003)]
- Oracle Night - Paul Auster (2003)
- Pattern Recognition - William Ford Gibson (2003)
- The Pixel Eye - Paul Levinson (2003)
- The Quality of Life Report - Meghan Daum (2003)
- Sheet Music - M. J. Rose (2003)
- Shopaholic Ties the Knot - Sophie Kinsella (2003)
- Small Town - Lawrence Block (2003)
- What I Loved - Siri Hustvedt (2003)
- The Name of the Game - Will Eisner (2003)
- Absent Friends - S. J. Rozan (2004)
- An Almost Perfect Moment - Binnie Kirshenbaum (2004)
- Bergdorf Blondes - Plum Sykes (2004)
- Between Two Rivers - Nicholas Rinaldi (2004)
- Bombshell - Lynda Curnyn (2004)
- Down Here - Andrew Vachss (2004)
- The Green and the Gray - Timothy Zahn (2004)
- In the Shadow of No Towers - Art Spiegelman (2004)
- Joy Comes in the Morning - Jonathan Rosen (2004)
- Love Monkey - Kyle Smith (2004)
- Matzo Ball Heiress - Laurie Gwen Shapiro (2004)
- Monster Island - David Wellington (August 2004)
- The Island of Bicycle Dancers - Jiro Adachi (2004)
- Oh, Play That Thing - Roddy Doyle (2004)
- The Outside World - Tova Mirvis (2004)
- Solos - Kitty Burns Florey (2004)
- The Dark Tower VI: Song of Susannah - Stephen King (2004)
- Under the Manhattan Bridge - Irene Marcuse (2004)
- The White Rose - Jean Hanff Korelitz (2004)
- In Like Flynn - Rhys Bowen (2005)
- Brickhouse - Rita Ewing (2005)
- The Brooklyn Follies - Paul Auster (2005)
- Everyone Worth Knowing - Lauren Weisberger (2005)
- Extremely Loud and Incredibly Close - Jonathan Safran Foer (2005)
- The History of Love - Nicole Krauss (2005)
- The Hour of the Cat - Peter Quinn (2005)
- Love Creeps - Amanda Filipacchi (2005)
- Metropolis - Elizabeth Gaffney (2005)
- Pinkerton's Sister - Peter Rushforth (2005)
- The Island of Bicycle Dancers - Jiro Adachi (2005)
- Up From Orchard Street - Eleanor Widmer (2005)
- The Year of Magical Thinking - Joan Didion (2005)
- Oh Danny Boy - Rhys Bowen (2006)
- Beautiful Lies - Lisa Unger (2006)
- Nightlife - Rob Thurman (2006)
- The Emperor's Children - Claire Messud (2006)
- Mask Market - Andrew Vachss (2006)
- The Plot To Save Socrates - Paul Levinson (2006)
- Rise and Shine - Anna Quindlen (2006)
- The Righteous Men - Sam Bourne (2006)
- Size 12 Is Not Fat - Meg Cabot (2006)
- Size 14 Is Not Fat Either - Meg Cabot (2006)
- Moonshine - Rob Thurman (2007)
- Big Boned - Meg Cabot (2007)
- Queen of Babble in the Big City - Meg Cabot (2007)
- Exit Ghost - Philip Roth (2007)
- Deadstream - Brad Platt (2005)
- Madhouse - Rob Thurman (2008)
- Netherland - Joseph O'Neill (2008)
- Lush Life - Richard Price (2008)
- Chronic City - Jonathan Lethem (2009)
- Let the Great World Spin - Colum McCann (2009)
- Deathwish - Rob Thurman (2009)
- New York - Edward Rutherford (2009)
- The Thieves of Manhattan - Adam Langer (2010)
- Rockettes, Rockstars & Rockbottom - Keltie Colleen (2010)
- Tabloid City: A Novel - Pete Hamill (2011)
- The Darlings: A Novel - Cristina Alger (2012)
- The Gods of Gotham - Lyndsay Faye (2012)
Read more about this topic: List Of Books Set In New York City, Books For Adults, Twenty-First Century