S
- Savoy - Paul Waaktaar-Savoy, Lauren Savoy
- Set Your Goals (band)
- Shakespears Sister (1989–1993) - Siobhan Fahey (alto), Marcella Detroit (soprano)
- Shiny Toy Guns
- Skillet
- Slightly Stoopid
- Simon & Garfunkel - Paul Simon, Art Garfunkel
- Sonic Syndicate - Richard Sjunnesson, Roland Johansson
- Sonic Youth - Thurston Moore, Kim Gordon, Lee Ranaldo
- Spice Girls
- The Spinners - Philippe Wynne, Bobby Smith
- Split Enz - Neil Finn, Tim Finn
- Squeeze
- Status Quo
- Stereo Total
- Styx - Dennis DeYoung, James "J.Y." Young, Tommy Shaw, Lawrence Gowan
- Super Junior - Yesung, Ryeowook, Kyuhyun
- Supertramp - Roger Hodgson, Rick Davies
- System of a Down - Serj Tankian, Daron Malakian
- Shinee
Read more about this topic: List Of Bands With More Than One Lead Vocalist