S
- Doug Sahm (1976, with a re-united Sir Douglas Quintet, and also with The Texas Tornadoes 1990)
- B. Savage (1979)
- Boz Scaggs (1998)
- Don Schlitz (1989)
- Bob Schneider (2001)
- John Schneider (1986)
- Schuyler, Knobloch & Bickhardt (1988)
- Earl Scruggs (1977, 2000 with Marty Stuart)
- Randy Scruggs (1990 "Will The Circle Be Unbroken")
- Charlie Sexton (2001 with Double Trouble, 2010 with Spoon)
- Will Sexton (1990 with the W. C. Clark Blues Revue)
- Whitey Shafer (1980, 1981 "Encore", 1985)
- Eldon Shamblin (1981 "Mandolin Special")
- Billy Joe Shaver (1980, 1983, 1985, 1997 with Kris Kristofferson)
- Robert Shaw (1979)
- Ricky Van Shelton (1988, 1991)
- Shenandoah (1990)
- Vonda Shepard (1998 with Indigo Girls)
- T. G. Sheppard (1983)
- Kenny Wayne Shepherd (1997)
- The Shins (2004)
- Michelle Shocked (1990, 2000 "Women in Song" classic encore)
- Sir Douglas Quintet (1981)
- Ricky Skaggs (1982, 1985, 1988, 1995, 1998)
- Sleepy LaBeef (1984 with The LeRoi Brothers)
- Darden Smith (1988, 1994)
- Todd Snider (1996)
- Son Volt (1997)
- Sons of the Pioneers (1984 "Legends")
- Sons of the San Joaquin (1991 "Salute to the Cowboy", 1996 with Michael Martin Murphey)
- Social Distortion (2011)
- Southern Pacific (1986)
- Esperanza Spalding (2009)
- Larry Sparks (1995)
- Regina Spektor (2007)
- Spoon (2003, 2005, 2010)
- Joe Stampley (1980)
- Ralph Stanley (1980, 1986 with Bill Monroe, 1995, 1997 classic encore, 2002)
- Stars
- Sufjan Stevens (2006)
- B. W. Stevenson (1976)
- Gary Stewart (1981)
- Redd Stewart (1984 "Legends")
- Doug Stone (1992)
- Joss Stone (2004)
- Storyville (1998)
- George Strait (1982, 1984, 1986, 1989)
- The Strangers (1982)
- Angela Strehli (1990 with the W. C. Clark Blues Revue)
- Strength in Numbers (1990)
- The String Cheese Incident (2001)
- Marty Stuart (1979, 1987, 1990, 2000)
- The Subdudes (1992)
- Joe Sun (1980)
- Sweethearts of the Rodeo (1987, 1990)
- The Swell Season (2009)
- Keith Sykes (1983)
- Sylvia (1986)
Read more about this topic: List Of Austin City Limits Performers