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- Ugly Betty (2006–2010), comedy/ drama
- UFO Hunters (The History Channel) (2008–2009), documentary / reality
- UFO Hunters (Sci Fi Channel) (2008) documentary / reality
- Unbeatable Banzuke (1995–2002), game show
- Undercover Boss (February 7, 2010 – present), reality
- Underdog (1964–1973), cartoon
- Undergrads (2001), animated comedy
- Unfabulous (2004–2007), teen sitcom
- Unhappily Ever After (1995–1999), sitcom
- The Unit (2006–2009), thriller/ drama
- United States of Tara (2009–2011), comedy/drama
- Unsolved Mysteries (1987–1999), non-fiction crime drama
- The Unusuals (2009), comedy drama
- Unwrapped (June 1, 2001 – present), food
- USA High (1997–1999), teen sitcom
Read more about this topic: List Of American Television Series