S
- Sábado Gigante (1962 – present), variety
- Sabrina, the Teenage Witch (1996–2003), sitcom
- Salute Your Shorts (1991–1992), teen comedy/ drama
- Samurai Jack (2001–2004), animated action/ adventure
- Sanctuary (October 3, 2008 – present), science fiction/ supernatural
- Sanford and Son (1972–1977), sitcom
- Santa Barbara (1984–1993), soap opera
- Saturday Night Live (October 11, 1975 – present), sketch comedy/ variety
- Sarah Silverman Program (2007–2010), comedy
- Saved by the Bell (1989–1993), teen sitcom
- Saving Grace (2007–2010), police drama
- School Pride (2010), reality
- Scrabble (1984-1989, 1993), game show
- Scrabble Showdown (September 17, 2011 - May 27, 2012), game show
- Scrubs (2001–2010), comedy/ drama
- Sea Hunt (1958–1961), adventure
- Sealab 2020 (1972), animated
- Sealab 2021 (2000–2005), animated comedy
- seaQuest DSV (1993–1996), science fiction
- Second Chance (1987), sitcom
- The Secret Adventures of Jules Verne (2000), science fiction/ horror
- The Secret Life of the American Teenager (July 1, 2008 – present), teen drama
- Secret Millionaire (2008, 2011), reality
- The Secret Circle (2011-2012), supernatural teen drama
- The Secret Storm (1954–1974), soap opera
- The Secret World of Alex Mack (1994–1998), comedy/ science fiction
- The Secrets of Isis (1975–1977), action
- Seinfeld (1989–1998), sitcom
- Sense and Nonsense (1951–1954), game show
- Sesame Street (November 10, 1969 – present), children's educational series
- Seven Days (1998–2001), science fiction
- Sex and the City (1998–2004), dramedy
- Shear Genius (2007–present), reality show
- She Spies (2002–2004), action/ adventure
- Shameless (2010–present), drama
- The Shield (2002–2008), crime drama
- Shindig! (1964-1966), musical variety
- Shorties Watching Shorties (2004), animated anthology/ comedy
- Sifl and Olly Show (1997–1999), comedy
- Silver Spoons (1982–1986), sitcom
- Simon & Simon (1981–1989), crime drama
- The Simple Life (2003–2007), reality
- The Simpsons ( December 17, 1989 – present), animated comedy
- The Sing-Off (December 14, 2009 – present), reality/ talent competition
- Sisters (1991–1996), drama
- The Six Million Dollar Man (1974–1978), science fiction/ action
- Six Feet Under (2001–2005), drama
- Skating with the Stars (2010), reality/ sports competition
- Skins (2011), teen drama
- The Slap Maxwell Story (1987–1988), sitcom
- Sledge Hammer! (1986–1988), sitcom
- Sleeper Cell (2005–2006), drama
- Sliders (1995–2000), science fiction
- Smallville (2000–2011), action/ adventure/ science fiction
- Small Wonder (1985–1989), sitcom/ science fiction
- The Smothers Brothers Comedy Hour (1967–1969), comedy/ variety
- The Smurfs (1981–1989), animated series
- So You Think You Can Dance (July 20, 2005 – present) reality/talent competition
- Sonic the Hedgehog (TV Series)
- Sonic Underground
- Sonic X (2003–2006), cartoon
- Soap (1977–1981), comedy/ situation drama
- Sons of Anarchy (September 3, 2008 – present), crime drama
- Sons of Tucson (2010), comedy
- The Sopranos (1999–2007), drama
- South Park (August 13, 1997 – present), animated sitcom
- Southland (April 9, 2009 – present), police procedural
- South of Nowhere (2005–2008), teen drama
- So Weird (1999–2001), teen drama
- Space Cases (1996–1997), science fiction
- Space Ghost Coast to Coast (1994–2008), animated talk show
- Space Patrol science fiction
- Space Precinct (1963–1964), space western
- Spider-Man and His Amazing Friends (1981–1983), animated action/ adventure
- Spin City (1996–2002), sitcom
- Sports Night (1998–2000), sitcom
- SportsCenter (1988–present), sports/news
- SpongeBob SquarePants (May 1, 1999 – present), children's animated comedy
- Stanley
- St. Elsewhere (1982–1988), medical drama
- Star Trek, science fiction
- Star Trek: The Animated Series (1973–1974)
- Star Trek: Deep Space Nine (1993–1999)
- Star Trek: Enterprise (2001–2005)
- Star Trek: The Original Series (1966–1969)
- Star Trek: The Next Generation (1987–1994)
- Star Trek: Voyager (1995–2001)
- Star Wars: Clone Wars (2003–2005), animated series
- Star Wars: The Clone Wars (October 3, 2008 – present), animated series
- Stargate Atlantis (2004–2009), science fiction
- Stargate SG-1 (1997–2007), science fiction
- Stargate Universe (2009–2011), science fiction
- State of Georgia (June 29, 2011 – present), sitcom
- Static Shock (2000–2004), animated series
- Step by Step (1991–1998), sitcom
- Steve Harvey (September 4, 2012 – present), talk show
- Surfside 6 (1960-1962), detective
- Sugarfoot (1957-1961), western
- The Suite Life of Zack & Cody (2005–2008), teen sitcom
- The Suite Life on Deck (2008–2011), teen sitcom
- Sunset Beach (1997–1999), soap opera
- Supernatural (September 13, 2005 – present), paranormal/ horror
- Surface (2005–2006), science fiction
- The Surreal Life (2003–2006), reality
- Survivor ( May 31, 2000 – present), reality competition
- Super Circus (1949–1956), circus
- The Super Mario Bros. Super Show! (1989), cartoon
- Super Mario World (1991), cartoon
- Switched at Birth (June 6, 2011 – present), teen drama
- Switch (1975–1978)
Read more about this topic: List Of American Television Series