E
- E! True Hollywood Story (1996 – present), documentary
- Early Edition (1996–2000), sci-fi/drama
- Eastbound & Down (February 15, 2009 – present), comedy
- Eastwick (2009–2010), supernatural/ comedy-drama
- Easy Money (2008–2009), comedy-drama
- Ed (2000–2004), comedy-drama
- Ed, Edd n Eddy (1999–2009), animated comedy
- The Ed Sullivan Show (1948–1971), variety
- The Edge of Night (1956–1984), soap opera
- Eight Is Enough (1977–1981), comedy-drama
- The Electric Company (1971–1977), children's
- The Electric Company (January 19, 2009 – present), children's education
- Eleventh Hour (2008–2009), crime drama/ mystery
- Eli Stone (2008–2009), musical dramedy
- Ellen (1994–1998), sitcom
- The Ellen DeGeneres Show (September 8, 2003 – present), talk show
- The Ellen Show (2001–2002), sitcom
- Ellery Queen (1975–1976), mystery
- Emergency! (1972–1977), medical drama/action
- Emeril Live (1997 – present), cooking
- Emily's Reasons Why Not (2006), sitcom
- Empty Nest (1988–1995), sitcom
- Endurance (2002–2008), reality
- Engaged and Underage (2007–2008), reality
- Entertainment Tonight (September 14, 1981 – present), news
- Entourage (2004–2011) comedy-drama
- Episodes (January 9, 2011 – present), sitcom / serial
- ER (1994–2009), medical drama
- E/R (1984–1985), sitcom
- Essence of Emeril (1994–1996, 2000 – present), cooking
- Eureka (July 18, 2006 – present), sci-fi
- Eve (2003–2006), sitcom
- The Eve Arden Show (1957–1958), sitcom
- Even Stevens (2000–2003), teen sitcom
- Evening Shade (1990–1994), sitcom
- The Event (2010–2011), drama
- Everwood (2002–2006), drama
- Everybody Hates Chris (2005–2009), sitcom
- Everybody Loves Raymond (1996–2005), sitcom
- The Evidence (2006), police procedural
- The Ex List (2008), dramedy
- Exposed (2006–2007), dating
- Extra (September 5, 1994 – present), entertainment news
- Extreme Makeover (2002–2007), reality
- Extreme Makeover: Home Edition (December 3, 2003 – present), reality
- Extreme Makeover: Weight Loss Edition (May 30, 2011 – present), reality
- Eye for an Eye (2004 – present), reality/ courtroom
- The Eyes of Nye (2005), science
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