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- Earling, Iowa – Albert J. Earling, Milwaukee Road officer
- East St. Louis, Illinois – Saint Louis
- Eaton, New Hampshire – Connecticut Governor Theophilus Eaton
- Ebensburg, Pennsylvania – Eben Lloyd (died in childhood)
- Eckley, California – Commodore John L. Eckley
- Eddington, Maine – Colonel Jonathan Eddy (officer in the American Revolution)
- Edgartown, Massachusetts – Edgar Stuart, Duke of Cambridge
- Edgecomb, Maine – Lord Edgecomb (a supporter of the colonists)
- Edison, Georgia and Edison, New Jersey – Thomas Edison
- Edroy, Texas – Ed Cubage and Roy Miller (co-founders)
- Edwardsville, Illinois – Ninian Edwards
- Effingham, New Hampshire – Howard family, who were Earls of Effingham
- El Macero, California – Bruce Mace (local landowner)
- Elbridge, New York – Elbridge Gerry
- Elizabeth, New Jersey – Lady Elizabeth Carteret (wife of colonial proprietor and statesman George Carteret)
- Elizabethton, Tennessee – Elizabeth MacLin Carter and Elizabeth McNabb (wives of two early settlers)
- Elizabethtown, Kentucky – Elizabeth Hynes (wife of early settler Andrew Hynes)
- Elkader, Iowa – Abd el-Kader (Algerian patriot)
- Ellensburg, Washington – Mary Ellen Shoudy (wife of John A. Shoudy, purchaser of local trading post and founder)
- Ellenville, New York – Ellen Snyder (settler)
- Ellicott, New York – Joseph Ellicott (agent of the Holland Land Company)
- Ellicott City, Maryland – John, Andrew, and Joseph Ellicott (founders)
- Ellsworth, Maine and Ellsworth, New Hampshire – Chief Justice Oliver Ellsworth
- Elmendorf, Texas – Henry Elmendorf (mayor of San Antonio)
- Elmore, Vermont – Colonel Samuel Elmore (landowner)
- Ely's, California – Benjamin Ely (first post master)
- Elyria, Ohio – Heman Ely (1817)
- Emery, South Dakota – S.M. Emery (landowner)
- Emeryville, California – Joseph Stickney Emery (local landowner)
- Emory, California – A. Emory Wishon (cement company official)
- Ennis, Montana – William Ennis (settler)
- Epperson, California – Brutus E Eperson (first postmaster)
- Errol, New Hampshire – James Hay, 15th Earl of Erroll
- Erving, Massachusetts – John Erving (early farmer landowner)
- Estes Park, Colorado – Joel Estes (founder)
- Euclid, Ohio – Euclid (Greek mathematician)
- Eugene, Oregon – Eugene Franklin Skinner
- Eunice, Louisiana – Eunice Pharr Duson (second wife of Curley Duson, the founder of the city)
- Eustis, Maine – Charles L. Eustis (early proprietor)
- Evan's Ranch, California – Alvira Evans (first postmaster)
- Evans, Colorado – John Evans
- Evanston, Illinois – John Evans
- Evansville, Indiana – Robert Morgan Evans
- Evansville, Wyoming – W.T. Evans (blacksmith)
- Evelyn, California – Evelyn Smith (wife of Borax company official)
- Everett, Massachusetts – Edward Everett (politician and educator)
- Ewing Township, New Jersey – Charles Ewing (Chief Justice of the New Jersey Supreme Court)
Read more about this topic: List Of American Places Named After People