1960s
- Conan O'Brien (1963– ) Coco was raised in an Irish Catholic family
- Sean Penn (1960– ) his mother was a Catholic of Irish descent
- Chris Penn (1965–2006) his mother was a Catholic of Irish descent
- Robert Downey, Jr. (1965– ) his father is of Irish descent
- Daniel Baldwin (1960– ) actor, producer and director, one of the Baldwin brothers his father is of Irish descent
- Stephen Baldwin (1966– ) actor, one of the Baldwin brothers his father is of Irish descent
- William Baldwin (1963– ) film actor, one of the Baldwin brothers his father is of Irish descent
- Matthew Broderick
- Edward Burns
- Dean Cain (1966– ) American actor.
- James Caviezel star of Passion of the Christ. His mother is of Irish descent
- Neil Flynn film and television actor. Noted for his role as "Janitor" in Scrubs.
- George Clooney (1961– ) Academy Award-winning actor, director, producer and screenwriter
- Stephen Colbert (1964– ) actor, comedian, and journalist. Despite French surname, is of mostly Irish descent.
- John Cusack (1966– )
- Patrick Dempsey (1966– ) film and television actor (Grey's Anatomy)
- Johnny Depp (1963– ) Academy Award-nominated American actor, former teen idol
- Matt Dillon (1964– ) Academy Award-nominated American actor, former teen idol
- Karen Duffy (1962– )
- Emilio Estevez (1962– ) film/television actor and director, his father, Martin Sheen, is half-Irish Catholic on his mother's side.
- Ramon Estevez (1963– ) actor, son Martin Sheen.
- Renée Estevez (1967– ) actress, daughter of Martin sheen.
- Chris Farley
- Jorja Fox (1968– )
- Brendan Fraser
- Janeane Garofalo is half-Irish, half-Italian
- Lauren Graham
- Kathy Griffin
- Anthony Michael Hall (1968– ) film/television actor, former teen star
- Bonnie Hunt (1961– ) actress, Irish-American Catholic
- Moira Kelly (1968– ) actress, Irish-Catholic
- Robert Kelly
- Matthew McConaughey (1969– ) Actor
- James McCaffrey
- Dylan McDermott
- Neal McDonough
- Rosie O'Donnell
- Mike O'Malley
- William Mapother (1965– ) actor and Tom Cruise's cousin on his part paternal (Lost).
- Tatum O'Neal youngest actor to win an Oscar
- Ellen Pompeo is half-Irish, half-Italian actress
- John C. Reilly
- Charlie Sheen (1965– ) film/television actor, his father, Martin Sheen, is half-Irish Catholic on his mother's side
- Molly Shannon
- Ben Stiller
- Julia Sweeney
- Maura Tierney
- Courtney Thorne-Smith
- Donnie Wahlberg
- Kate Walsh (1967– ) actress/television
- Luke Wilson (brother of Owen Wilson)
- Owen Wilson
- Andrew Wilson (1964– ) older brother Owen and Luke Wilson.
- Tom Cruise (1962– ) father was of partial Irish ancestry
- Paul Giamatti (1967– )
- Dermot Mulroney (1963– ) actor. Is of predominantly Irish ancestry
Read more about this topic: List Of American Actors Of Irish Descent