1950s
- Pierce Brosnan (1953– ) actor (he is an American citizen since 2004).
- Baldwin brothers father is of Irish heritage
- Steve Buscemi
- Lenny Clarke
- David Caruso actor, (Mother is Irish-American, Father is Italian-American)
- Kevin Costner celebrity actor, of Native American, Irish and German descent
- Tim Daly (1956– ) stage, television and film actor, producer and director
- Bo Derek
- Joe Estevez actor and brother of Martin Sheen, mother was an immigrant from Ireland
- Jeff Fahey (1952– ) (Lost)
- Peter Gallagher
- Mel Gibson (1956 – ) actor, director and producer, his mother is an immigrant from Ireland
- Patricia Heaton
- Marg Helgenberger is of German and Irish ancestry
- Nathan Lane
- Denis Leary
- Bill Maher
- John C. McGinley
- Kate Mulgrew (1955– ) Best known for her role as Captain Kathryn Janeway on Star Trek: Voyager, and Mary Ryan on the soap opera Ryan's Hope, about an Irish-American family
- Bill Murray (1950– ) Academy Award-nominated, Emmy-winning and Golden Globe-winning comedian and actor
- Michael O'Keefe
- Terry O Quinn (1952– ) American actor best known for his role in Lost.
- Annette O'Toole (1952– ) American actress known for his roles in Smallville and Superman III
- Colin Quinn
- Mickey Rourke
- John Sayles (1950– ) independent film director and writer, frequently takes a small part in his own and other indie films
- John Travolta Is of Irish-Italian ancestry
- Dana Delany (1956– ) stage, television and film actor, star of China Beach, Desperate Housewives and Body of Proof
Read more about this topic: List Of American Actors Of Irish Descent