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- Juan Sabines Guerrero - Governor of Chiapas (Universidad Iberoamericana)
- Giovanni Girolamo Saccheri - Italian Jesuit and mathematician (Jesuit College in Milan)
- Antoine de Saint-Exupéry - French writer and aviator (Jesuit schools in Montgré and Le Mans)
- Grégoire de Saint-Vincent - Jesuit mathematician who independently discovered the Mercator series, the expansion of log (1 + x) in ascending powers of x.
- Saint Francis de Sales - Bishop of Geneva, Church Doctor, Clermont, Paris
- Antonin Scalia - American judge (Xavier High School and Georgetown University)
- C.A. Scarpello - American musician and sociological observer (St. Joseph's University)
- Christoph Scheiner - German astronomer and Jesuit (Jesuit Latin School in Augsburg and Jesuit College at Landsberg)
- Edward Schillebeeckx - American liberation theologian and priest of the Dominican Order
- Gaspar Schott - German physicist, mathematician and natural philosopher (studied under Athanasius Kircher)
- Kurt Schuschnigg - Austrian chancellor imprisoned in the Dachau concentration camp in 1938 by Nazi Germany following the Anschluss (Stella Matutina (Jesuit school))
- Vin Scully - American sportscaster (started as a student broadcaster at Fordham Preparatory School, Fordham University)
- Egon Sendler, S.J. - French priest, expert on Eastern Christian iconography (Collegium Russicum)
- Antonio Serrano - Mexican film director/screenwriter (Sexo, Pudor y Lágrimas) (Universidad Iberoamericana, Mexico)
- J. Francisco Serrano Cacho - Mexican architect. (Universidad Iberoamericana)
- Bartlett Sher - Tony-winning theater director (St. Ignatius College Preparatory, San Francisco, College of the Holy Cross)
- John Sexton - President of New York University (Brooklyn Prep and Fordham University)
- Mark Shriver - CEO, Save the Children (College of the Holy Cross)
- Don Shula - American football head coach (John Carroll University)
- Eugene Shvidler - billionaire and international oil tycoon (Fordham University)
- Carlos de Sigüenza y Góngora - Jesuit priest and early intellectual born in the Spanish viceroyalty of New Spain (Jesuit College in Tepoztlan)
- Paul Silas - American basketball player and head coach (Creighton University)
- Curtis Sliwa - American founder of the Guardian Angels (Brooklyn Prep)
- Saravanan Sivakumar - Tamil actor (Loyola College, Chennai)
- Santosh Sivan - Indian cinematographer and film director (Loyola School, Thiruvananthapuram)
- Tom Snyder - American TV/radio talk show host (Marquette University High School)
- Demetrio Sodi - Mexican politician (Universidad Iberoamericana)
- Francis Cardinal Spellman - Cardinal and Archbishop of New York (Fordham University)
- Tomáš Špidlík, S.J. - Czech Jesuit Cardinal, scholar, author and professor (Pontifical Oriental Institute)
- Erik Spoelstra - NBA head coach (Jesuit High School in Portland, Oregon)
- Charlie Stayers - Guyanese and West Indian cricketer (St. Stanislaus College, Guyana)
- John Stockton - American basketball player (Gonzaga University)
- Peter Sutherland - Former DG of GATT, Former Attorney General of Ireland, Board Member at BP and Goldman Sachs (Gonzaga College, Dublin)
- Yi Su-gwang - Korean scholar and a military officer (studied under Fr. Matteo Ricci, S.J.)
- Robert Surcouf - French privateer
- Jean-Joseph Surin - French Jesuit mystic (Collège de Clermont)
- Kenneth Suzuki - American association executive and magazine editor (Le College des Jesuites in Quebec City, Canada)
- Alexius Sylvius Polonus - Polish Jesuit astronomer and maker of astronomical instruments (Jesuit College in Kalisz, Poland)
Read more about this topic: List Of Alumni Of Jesuit Educational Institutions