TL
- tl – (s) Tagalog language (ISO 639-1 code)
- Tl – (s) Thallium
- TL
- (i) Team Leader
- (s) Teralitre
- Timor-Leste (ISO 3166 digram)
- (p) ThermoLuminescence
- TLATOJL – The Life and Times of Juniper Lee
- TLA – (i) Three-Letter Abbreviation/Acronym
- TLAM – (i) Tomahawk Land Attack Missile
- TLAR
- (i) That Looks About Right (chat shorthand)
- Transporter-Launcher And Radar
- TLC
- (i) Tender Loving Care
- The Learning Channel (now known strictly by the initials)
- Thin Layer Chromatography
- T-Boz, Lefteye, Chilli
- Tables, Ladders, and Chairs (type of professional wrestling match)
- TLD
- (i) Thermoluminescent Dosimeter
- Top-Level Domain
- TLM
- (i) Traditional Latin Mass
- Tridentine Latin Mass
- Transaction Lifecycle Management
- TLS
- (s) Timor-Leste (ISO 3166 trigram)
- (i) Times Literary Supplement
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