CL
- Cl – (s) Chlorine
- CL – (s) Chile (ISO 3166 digram) – (i) Co-ordination Line – One Hundred and Fifty (in Roman numerals)
- CLA – (i) Clutterers Anonymous
- CLEC – (i) Competitive Local Exchange Carrier
- CLEMARS – (a) California Law Enforcement Mutual Aid Radio System
- CLI – (i) Command Line Interface/Interpreter
- CLIC – (p) Compact LInear Collider
- CLO – (i) Cornell Lab of Ornithology
- CLOB – (p) Character Large OBject
- CLOS – (i) Command to Line-Of-Sight (missile control system)
- CLOS – (a) Common Lisp Object System
- CLP – (s) Chilean peso (ISO 4217 currency code) – (i) Common Land Picture
- CLPFC – (i) CentroLateral PreFrontal Cortex
- CLRP – (a) College Loan Repayment Program
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