1943
- January 21 – Pan Am Flight 1104, a Martin M-130 nicknamed the Philippine Clipper, crashes into a mountain near Boonville, California, killing all 19 passengers and crew, including Rear-Admiral Robert H. English, commander of the U.S. Pacific Submarine Fleet.
- June 1 – BOAC Flight 777, a Douglas DC-3, is shot down by Luftwaffe fighter aircraft over the Bay of Biscay, killing 17 passengers and crew, including actor Leslie Howard and leading to speculation that the flight was attacked because German intelligence believed that British Prime Minister Winston Churchill was aboard.
- July 28 – American Airlines Flight 63 (Flagship Ohio), a Douglas DC-3, loses control due to severe turbulence and violent downdrafts and crashes near Trammel, Kentucky, killing twenty out of twenty-two people on board.
- October 15 – American Airlines Flight 63 (Flagship Missouri), a DC-3, crashes near Centerville, Tennessee, killing all eight passengers and three crewmembers, after ice formed on its wings and propeller.
Read more about this topic: List Of Accidents And Incidents Involving Commercial Aircraft