Dosage
Lisdexamfetamine is marketed under the brand name Vyvanse. Vyvanse comes in several dosages (see table below). These are usually labeled to be taken once daily.
| Vyvanse dosage strengths available | ||
|---|---|---|
| Strength | Appearance | Imprint (unique label) |
| 20 milligrams | Capsule with ivory colored body and cap | NRP104 or S489 20 mg |
| 30 milligrams | Capsule with white colored body and orange colored cap | NRP104 or S489 30 mg |
| 40 milligrams | Capsule with white colored body and teal colored cap | NRP104 or S489 40 mg |
| 50 milligrams | Capsule with white colored body and blue colored cap | NRP104 or S489 50 mg |
| 60 milligrams | Capsule with aqua blue colored body and cap | NRP104 or S489 60 mg |
| 70 milligrams | Capsule with blue colored body and orange colored cap | NRP104 or S489 70 mg |
25 mg of Vyvanse is molecularly equivalent to 10 mg of Dexedrine (resulting in or including 7.37 mg versus 7.50 mg dextroamphetamine, respectively), although a 25 mg Vyvanse capsule is not commercially available. However, the molecular equivalence ratio does not mean that the respective doses of Vyvanse and Dexedrine SR (Spansule) are bioequivalent because the two formulations have slightly different pharmacokinetic profiles. For example, while the area under the curve for the aforementioned pharmaceuticals is equivalent, the peak exposure (Cmax) to the active compound dextroamphetamine is about 50% higher for Vyvanse than for Dexedrine SR. The conversion rate of lisdexamfetamine to dextroamphetamine base is 0.2948, meaning that each milligram of lisdexamfetamine is equivalent to 0.2948 mg of dextroamphetamine base.
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