Lipoprotein-associated Phospholipase A2

Lipoprotein-associated Phospholipase A2

Identifiers Symbols PLA2G7; LDL-PLA2; LP-PLA2; PAFAD; PAFAH External IDs OMIM: 601690 MGI: 1351327 HomoloGene: 3725 ChEMBL: 3514 GeneCards: PLA2G7 Gene EC number 3.1.1.47

Gene Ontology
Molecular function	• 1-alkyl-2-acetylglycerophosphocholine esterase activity • phospholipid binding • calcium-independent phospholipase A2 activity
Cellular component	• extracellular region • low-density lipoprotein particle
Biological process	• lipid catabolic process • low-density lipoprotein particle remodeling • lipid oxidation • plasma lipoprotein particle oxidation • cellular protein metabolic process • positive regulation of inflammatory response • positive regulation of monocyte chemotaxis
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 7941 27226 Ensembl ENSG00000146070 ENSMUSG00000023913 UniProt Q13093 Q60963 RefSeq (mRNA) NM_001168357 NM_013737 RefSeq (protein) NP_001161829 NP_038765 Location (UCSC) Chr 6:
46.67 – 46.7 Mb Chr 17:
43.57 – 43.61 Mb PubMed search

Lipoprotein-associated phospholipase A₂ (Lp-PLA₂) also known as platelet-activating factor acetylhydrolase (PAF-AH) is a phospholipase A2 enzyme that in humans is encoded by the PLA2G7 gene. Lp-PLA₂ is a 45-kDa protein of 441 amino acids. It is one of several PAF acetylhydrolases.