LHB may refer to:
- The University of Texas Longhorn Band, a marching band
- Linke-Hofmann-Busch (LHB), now Alstom LHB, a German rail vehicle manufacturer
- Late Heavy Bombardment, a period in the Earth's early history
- Local Health Board, an administrative unit within the National Health Service in Wales
- Luteinizing hormone beta polypeptide, a protein