The let-7 Family
The lethal-7 (let-7) gene was first discovered in the nematode as a key developmental regulator and became one of the first two known microRNAs (the other one is lin-4). Soon, let-7 was found in fruit fly, and identified as the first known human miRNA by a BLAST (basic local alignment search tool) research. The mature form of let-7 family members is highly conserved across species.
Read more about this topic: Let-7 Micro RNA Precursor
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