Leopold II may refer to:
- Leopold II, Grand Duke of Tuscany (1797–1870), Grand Duke of Tuscany
- Leopold II, Holy Roman Emperor (1747–1792), Archduke of Austria
- Leopold II, Margrave of Austria (1050–1095), fifth Margrave of Austria
- Leopold II, Prince of Anhalt-Dessau (1700–1751), Prussian general
- Leopold II, Prince of Lippe (1796–1851), eldest child of Leopold I and Princess Pauline
- Leopold II of Belgium (1835–1909), King of the Belgians