LEKTI

LEKTI

Identifiers Symbols SPINK5; LEKTI; LETKI; NETS; NS; VAKTI External IDs OMIM: 605010 MGI: 1919682 HomoloGene: 4987 GeneCards: SPINK5 Gene

Gene Ontology
Molecular function	• serine-type endopeptidase inhibitor activity
Cellular component	• extracellular region • cytoplasm • endoplasmic reticulum • endoplasmic reticulum membrane • cytosol • cell cortex • perinuclear region of cytoplasm • epidermal lamellar body
Biological process	• epidermal cell differentiation • negative regulation of angiogenesis • regulation of cell adhesion • extracellular matrix organization • epithelial cell differentiation • hair cell differentiation • anagen • regulation of T cell differentiation • negative regulation of proteolysis • negative regulation of immune response
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 11005 72432 Ensembl ENSG00000133710 ENSMUSG00000055561 UniProt Q9NQ38 Q148R4 RefSeq (mRNA) NM_001127698 NM_001081180 RefSeq (protein) NP_001121170 NP_001074649 Location (UCSC) Chr 5:
147.41 – 147.52 Mb Chr 18:
43.96 – 44.02 Mb PubMed search

Lympho-epithelial Kazal-type-related inhibitor (LEKTI) also known as serine protease inhibitor Kazal-type 5 (SPINK5) is a protein that in humans is encoded by the SPINK5 gene.