Lefty may refer to:
- left-handedness
- A nickname for a person who is left-handed or an adherent of left-wing politics
- The Tale of Cross-eyed Lefty from Tula and the Steel Flea by Leskov
- Lefty (1964 film), an animated film by Ivan Ivanov-Vano
- Lefty (1986 film)
- Lefty (ballet)
- Lefty, a super computer used at Cornell University for research on South Korean products
- Lefty the Salesman, a Sesame Street character
- Lefty shock, a front shock on some Cannondale bicycle wheels
- Lefty, a 1988 album by Art Garfunkel
- "Lefty", a song by Soft Machine from the album Six
- LEFTY, Vernon/Kelowna, BC, Canada Rock Band
- Lefty, proteins that are closely related members of the TGF-beta family of growth factors
Read more about Lefty: People With The Nickname