Leader peptidase A (LepA) is an elongation factor that is thought to back-translocate on the ribosome during the translation of RNA to proteins in all prokaryotes and eukaryotes that have maintained functioning mitochondria. There are three primary elongation factors (EF-G, EF-Tu, EF-Ts) that are known to be the main contributors to facilitate elongation during protein synthesis; due to LepA's now acknowledged proofreading function in translation, scientists are now lobbying to have LepA renamed as EF-4 (elongation factor 4).
Read more about Leader Peptidase A: Evolutionary Background, Structure, Function, Activity, Experimental Data
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