| Year |
Title |
Role |
Notes |
| 1992 |
Lorenzo's Oil |
Young Teacher |
|
| 1993 |
Dave |
Randi |
|
| Class of '61 |
Lily Magraw |
TV |
| Tales of the City |
Mary Ann Singleton |
TV Mini-Series: 1 Episode |
| Searching for Bobby Fischer |
School Teacher |
|
| Blind Spot |
Phoebe |
TV |
| 1994 |
Law & Order |
Martha Bowen |
TV Series: 1 Episode |
| Simple Twist of Fate, AA Simple Twist of Fate |
Nancy Lambert Newland |
|
| 1995 |
Congo |
Dr. Karen Ross |
|
| 1996 |
Primal Fear |
Janet Venable |
|
| 1997 |
Absolute Power |
Kate Whitney |
|
| 1998 |
Truman Show, TheThe Truman Show |
Meryl Burbank/Hannah Gill |
Nominated — Blockbuster Entertainment Award for Favorite Supporting Actress – Drama |
| More Tales of the City |
Mary Ann Singleton |
TV Mini-Series: 6 Episodes |
| 1999 |
Love Letters |
Melisa Gardner Cobb |
TV |
| Lush |
Rachel Van Dyke |
Nominated — DVD Premiere Award for Best Actress |
| 2000 |
House of Mirth, TheThe House of Mirth |
Bertha Dorset |
Nominated — Toronto Film Critics Association Award for Best Supporting Actress |
| You Can Count on Me |
Samantha 'Sammy' Prescott |
- Boston Society of Film Critics Award for Best Actress
- Dallas-Fort Worth Film Critics Association Award for Best Actress
- Los Angeles Film Critics Association Award for Best Actress
- National Society of Film Critics Award for Best Actress
- New York Film Critics Circle Award for Best Actress
- San Diego Film Critics Society Award for Best Actress
- Southeastern Film Critics Association Award for Best Actress
- Toronto Film Critics Association Award for Best Actress
- Vancouver Film Critics Circle Award for Best Actress
- Nominated — Academy Award for Best Actress
- Nominated — Chicago Film Critics Association Award for Best Actress
- Nominated — Chlotrudis Award for Best Actress
- Nominated — Golden Globe Award for Best Actress - Motion Picture Drama
- Nominated — Independent Spirit Award for Best Lead Female
- Nominated — Online Film Critics Society Award for Best Actress
- Nominated — Phoenix Film Critics Society Award for Best Actress
- Nominated — Satellite Award for Best Actress - Motion Picture Drama
- Nominated — SAG Award for Outstanding Performance by a Female Actor in a Leading Role
|
| Maze |
Callie |
|
| Running Mates |
Lauren Hartman |
TV |
| 2001 |
Wild Iris |
Iris Bravard |
TV
- Emmy Award for Outstanding Lead Actress – Miniseries or a Movie
- Nominated — Satellite Award for Best Actress - Miniseries or Television Film
|
| Further Tales of the City |
Mary Ann Singleton |
TV Mini-Series: 3 Episodes |
| 2002 |
Mothman Prophecies, TheThe Mothman Prophecies |
Officer Connie Mills |
Fangoria Chainsaw Award for Best Actress |
| Laramie Project, TheThe Laramie Project |
Sherry Johnson |
|
| 2003 |
Life of David Gale, TheThe Life of David Gale |
Constance Harraway |
|
| Mystic River |
Annabeth Markum |
- Boston Society of Film Critics Award for Best Cast
- Nominated — BAFTA Award for Best Actress in a Supporting Role
- Nominated — Screen Actors Guild Award for Outstanding Performance by a Cast in a Motion Picture
|
| Love Actually |
Sarah |
Nominated — Phoenix Film Critics Society Award for Best Cast |
| 2003–04 |
Frasier |
- Mindy (1 episode)
- Charlotte (5 episodes)
|
TV Series
Emmy Award for Outstanding Guest Actress – Comedy Series |
| 2004 |
Kinsey |
Clara McMillen |
- Florida Film Critics Circle Award for Best Supporting Actress
- Glitter Award for Best Actress
- National Board of Review Award for Best Supporting Actress
- Phoenix Film Critics Society Award for Best Supporting Actress
- Southeastern Film Critics Association Award for Best Supporting Actress
- Nominated — Academy Award for Best Supporting Actress
- Nominated — Broadcast Film Critics Association Award for Best Supporting Actress
- Nominated — Dallas-Fort Worth Film Critics Association Award for Best Supporting Actress
- Nominated — Golden Globe Award for Best Supporting Actress - Motion Picture
- Nominated — London Film Critics Circle Award for Best Actress
- Nominated — National Society of Film Critics Award for Best Supporting Actress
- Nominated — Online Film Critics Society Award for Best Supporting Actress
- Nominated — Satellite Award for Best Supporting Actress - Motion Picture
- Nominated — SAG Award for Outstanding Performance by a Female Actor in a Supporting Role
- Nominated — Vancouver Film Critics Circle Award for Best Actress
- Nominated — Washington D.C. Area Film Critics Association Award for Best Supporting Actress
|
| P.S. |
Louise Harrington |
Mar del Plata Film Festival Award for Best Actress
Nominated — Satellite Award for Best Actress - Motion Picture Drama |
| 2005 |
Exorcism of Emily Rose, TheThe Exorcism of Emily Rose |
Erin Bruner |
Nominated — Fangoria Chainsaw Award for Best Heroine
Nominated — Saturn Award for Best Actress |
| Squid and the Whale, TheThe Squid and the Whale |
Joan Berkman |
- Austin Film Critics Association Award for Best Supporting Actress
- Gotham Award for Best Ensemble Cast
- Las Palmas Film Festival Award for Best Actress
- Satellite Award for Best Supporting Actress - Motion Picture Drama
- Toronto Film Critics Association Award for Best Actress
- Nominated — Golden Globe Award for Best Actress - Motion Picture Musical or Comedy
- Nominated — Independent Spirit Award for Best Lead Female
- Nominated — St. Louis Gateway Film Critics Association Award for Best Actress
- Nominated — Vancouver Film Critics Circle Award for Best Actress
|
| 2006 |
Jindabyne |
Claire |
- Valladolid International Film Festival Award for Best Actress
- Nominated — Australian Film Institute Award for Best Actress in a Leading Role
- Nominated — Film Critics Circle of Australia Award for Best Actress in a Lead Role
- Nominated — IF Award for Best Actress
|
| Driving Lessons |
Laura Marshall |
|
| Man of the Year |
Eleanor Green |
|
| Hottest State, TheThe Hottest State |
Jesse |
|
| The Armenian Genocide |
Maria Jacobsen |
Documentary |
| 2007 |
Breach |
Kate Burroughs |
|
| Savages, TheThe Savages |
Wendy Savage |
- Ft. Lauderdale International Film Festival Jury Award for Best Actress
- Nominated — Academy Award for Best Actress
- Nominated — Chicago Film Critics Association Award for Best Actress
- Nominated — Detroit Film Critics Society Award for Best Actress
- Nominated — Dallas-Fort Worth Film Critics Association Award for Best Actress
- Nominated — Gotham Award for Best Ensemble Cast
- Nominated — Houston Film Critics Society Award for Best Actress
- Nominated — London Film Critics Circle Award for Best Actress
- Nominated — Online Film Critics Society Award for Best Actress
- Nominated — Satellite Award for Best Actress - Motion Picture Drama
|
| Nanny Diaries, TheThe Nanny Diaries |
Mrs. X |
|
| 2008 |
John Adams |
Abigail Adams |
TV Mini-Series: 7 Episodes
- Emmy Award for Outstanding Lead Actress – Miniseries or a Movie
- Golden Globe Award for Best Actress - Miniseries or TV Film
- Gracie Allen Award for Outstanding Female Lead - Drama Special
- Screen Actors Guild Award for Outstanding Female Actor - Miniseries or Television Film
- Nominated — Satellite Award for Best Actress - Miniseries or Television Film
|
| City of Your Final Destination, TheThe City of Your Final Destination |
Caroline |
Method Fest Independent Film Festival Award for Best Actress |
| Other Man, TheThe Other Man |
Lisa |
|
| 2009 |
Morning |
Dr. Goodman |
|
| Sympathy for Delicious |
Nina Hogue |
|
| 2009-present |
PBS Masterpiece |
Host |
|
| 2010–present |
Big C, TheThe Big C |
Cathy Jamison |
TV Series: 36 Episodes
Also Executive Producer
- Satellite Award for Best Actress – Television Series Musical or Comedy
- Golden Globe Award for Best Actress – Television Series Musical or Comedy
- Nominated — Primetime Emmy Award for Outstanding Lead Actress in a Comedy Series
- Nominated — Satellite Award for Best Actress - Television Series Musical or Comedy
- Nominated — Golden Globe Award for Best Actress – Television Series Musical or Comedy
|
| 2011 |
Details, TheThe Details |
Lila |
|
| Arthur Christmas |
North Pole Computer |
Voice Only |
| 2012 |
Hyde Park on Hudson |
Margaret Suckley |
post-production |