Laff may refer to:
- Laff Records, an independent record label
- The Laff Stop, a comedy club in Houston, Texas
- Laff Trax Comedy Theatre, a comedy production house
- Laff-A-Lympics, a Saturday morning cartoon series
- Los Angeles Film Festival, an annual film festival held in Westwood, Los Angeles, California.
- Latin American Foundation for the Future, a UK based charity supporting street, working and vulnerable children in Peru.