Dune
The Bene Gesserit breeding program had been conducted for centuries to preserve important bloodlines, but with the Kwisatz Haderach as its primary goal. A product of the program herself, Lady Jessica, concubine to the Duke Leto Atreides, had been instructed to bear him a daughter, but no sons. This daughter was to be wed to Feyd-Rautha, nephew of Baron Vladimir Harkonnen and heir to House Harkonnen, healing the generations-old rift between House Atreides and House Harkonnen. However, Jessica fell in love with Leto, and produced for him the son he desired: Paul Atreides. The Sisterhood is furious at Jessica's disobedience, but still somewhat intrigued by the potential in Paul, who, it turns out, is indeed the Kwisatz Haderach, a generation earlier than expected. Unprepared for his early arrival, the Bene Gesserit fail to control the young man as planned; by seizing control of the planet Arrakis and the all-important spice melange, Paul manages to seize control of the Known Universe. The very superbeing for whom the Bene Gesserit had schemed and waited becomes the instrument by which their order is diminished.
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