KSL may refer to:
- KSL (AM), a radio station (1160 AM) licensed to serve Salt Lake City, Utah, United States
- KSL-FM, a radio station (102.7 FM) licensed to serve Midvale, Utah
- KSL-TV, a television station (digital UHF 38, virtual 5) licensed to serve Salt Lake City, Utah
- Kate Sharpley Library
- The National Rail station code for Kearsley railway station, England
- Kenyan Sign Language
- Key Sounds Label, a Japanese record label
- Khalid Sheikh Mohammed
- Knights of St Lazarus
- Knowledge Systems Laboratory
- Korean Sign Language
- Kowloon Southern Link (KCR), a planned railway link in Hong Kong
- synthesized peptide, KVFNH2, which may be an antimicrobial agent useful in fighting dental plaque
- Kayo Samuel Luke - Makers of the comic series Irony & randomness