Treatment
There is no definitive treatment for Kleine–Levin syndrome. Stimulants, including amphetamines, methylphenidate, and modafinil, administered orally, can be used to treat sleepiness, but do not improve sluggish cognition or other elements of the altered mental state. There are some similarities between Kleine–Levin syndrome and bipolar disorder, and lithium and carbamazepine are reported to be beneficial in some cases in warding off or shortening episodes. Responses to treatment have often been limited. This disorder needs to be differentiated from cyclic re-occurrence of sleepiness during the premenstrual period in teenage girls that may be controlled with hormonal contraception.
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