Frequency and Duration of Episodes
A 2005 review of the scientific literature reported that the disease had an estimated median duration of 8 years in 186 KLS patients. Among the subset of 65 patients who had reportedly recovered, the average age was 23 and the median duration was 4 years. The duration of the disease did not seem to be influenced by the age of onset or the presence of hypersexuality.
Patients experienced an average of 12 episodes lasting an average of 12 days, although the range of symptoms reported varied from 2 to 130 episodes and lasted between 2.5 and 80 days. Subjects experienced an average duration of 6 months between episodes, but this ranged from .5 to 72 months. Subjects typically experienced less frequent and less intense attacks towards the end of the disease course, and the subject is considered cured if they do not experience an episode for 6 or more years.
A subsequent study by the same authors of 108 patients, however, found that the disease duration, at least in this disease cohort, was longer in men, those suffering hypersexuality and where the age of onset was after 20.
Read more about this topic: Kleine-Levin Syndrome
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