KISN may refer to:
- The ICAO code for Sloulin Field International Airport in Williston, North Dakota, United States
- KISN (FM), a radio station (96.7 FM) licensed to Belgrade, Montana, United States
- KISN (Portland), defunct AM and FM radio stations in Portland, Oregon, United States
- KZHT, a radio station (97.1 FM) licensed to Salt Lake City, Utah, United States, which used the call sign KISN or KISN-FM until January 2004