Kis or KIS may refer to:
- Kis (surname)
- KIS (weapon), a Polish machine pistol used during World War II
- Kis language, spoken in Papua New Guinea
- Cusae, a city in Upper Egypt
- Kaspersky Internet Security, an Internet security suite developed by Kaspersky Lab
- Kim Il-sung (1912–1994), leader of North Korea
- Knowbot Information Service, a user interface to a variety of remote directory services
- Kohan: Immortal Sovereigns, a high fantasy real-time strategy game
- Kosovo Is Serbia, a media campaign in Serbia
- Keep It Simple, a common phrase for simplicity; see KISS principle
- -kis-, from the Greek word, κις, meaning "times", forming a Greek multiple numerical prefix