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- Daniel Killer, former Argentine footballer
- Killer, Germany, a village in the town of Burladingen, in the Killertal valley
- Killer (philately), term for a heavy stamp cancellation mark
- Killer (computer), an AT&T public-access UNIX machine involved in Operation Sundevil
- Killer NIC, a network interface card manufactured by Bigfoot Networks
- Killer application or killer app, a computer program that is so necessary or desirable that it proves the core value of some larger technology
- TNFRSF10B, tumor necrosis factor receptor superfamily, member 10b, a human gene
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