Khosla is a surname of Indian origin. It may refer to:
- Vinod Khosla, Indian-born American venture capitalist
- Rohit Khosla, Indian fashion designer
- Neeru Khosla, Co-Founder of the non-profit CK12 Foundation
- Raj Khosla, Indian film director
- Pradeep Khosla, Indian American computer scientist
- Sanjay Khosla, Indian-American engineer