Khamiso Goth (Urdu: خمیسو گوٹھ ) is one of the neighbourhoods of New Karachi Town in Karachi, Sindh, Pakistan.
There are several ethnic groups in Khamiso Goth including Muhajirs, Sindhis, Kashmiris, Seraikis, Pakhtuns, Balochis, Memons, Bohras, Ismailis, etc. Over 99% of the population is Muslim. The population of New Karachi Town is estimated to be nearly one million.