Khali and similar can mean:
- An empty beat indicating the beginning of a subdivision in the taal rhythmic cycle
- The Great Khali, an Indian professional wrestler, actor, and former powerlifter
- Rub' al Khali, a large desert in Arabia
- Simbi Khali, born April 28, 1971, an American actress
- Nira Khali, a fictional character from the Saga of Seven Suns series of novels by Kevin J. Anderson
- Ksar el Khali, a town in central-northern Mauritania