Surname
- Abdelaziz Belkhadem (born 1945), Algerian politician
- Ali Khademhosseini (born 1975), Iranian-Canadian bioengineer
- Amir Reza Khadem (born 1970), Iranian wrestler
- Dhikru'llah Khadem (1904–1986), Iranian Hand of the Cause
- Mohammad Khadem (born 1935), Iranian wrestler
- Rasoul Khadem (born 1972), Iranian wrestler
- Samir El-Khadem (born 1942), Lebanese former Commander of the Lebanese Naval Forces
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