Kessler or Keßler (in German) may refer to:
- Kessler (automobile), an American automobile made 1921–1922
- Kessler (name), people named Kessler
- Kessler (TV series), a British television series from 1981
- Kessler Syndrome, a scenario, proposed by NASA consultant Donald J. Kessler, involving space debris
- Kessler Whiskey, an American brand of blended whiskey