Keepsake may refer to:
- Souvenir, a (small) item that reminds a person of a specific event or time
- Keepsake (computer game), an adventure computer game
- Keepsake (quartet), a barbershop quartet
- Keepsake (band), an influential emo band
- Giftbook, another name for a giftbook or annual
- "Keepsake", a track from The Gaslight Anthem's 2012 album, Handwritten